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ceftolozane / tazobactam

J - Antiinfectives For Systemic Use -> J01 - Antibacterials For Systemic Use -> J01D - Other Beta-Lactam Antibacterials -> J01DI - Other Cephalosporins -> J01DI54 - Zerbaxa
Administration category: Limited Medicine group: antibacterial File parts: ceftolozane tazobactam Brand name: Zerbaxa

Standard dosages

≥ 18 years
Weight ROA Load Dosage
ROA:
iv
Load:
-
Dosage:
1000/500mg 3 dd

Kidney function

≥ 18 years
ROA GFR Dosage Interval Comments
ROA: iv
GFR:
30 - 50
Dosage:
500 mg ceftolozaan + 250 mg tazobactam
Comments:
3 dd
GFR:
15 - 30
Dosage:
250 mg ceftolozaan + 125 mg tazobactam
Comments:
3 dd
GFR:
5 - 15
Dosage:
eenmalige oplaaddosis 500 mg ceftolozaan en 250 mg tazobactam, na 8 uur 100 mg ceftolozaan + 50 mg tazobactam 3 dd
Renal elimination: 95%
Dosage: dependent on kidney function

Renal function-replacement therapy

Hemo dialysis: eenmalige oplaaddosis van 500 mg/250 mg gevolgd door een onderhoudsdosis van 100 mg/50 mg elke 8 uur. Op dagen van hemodialyse de dosis zo snel mogelijk na de hemodialyse toedienen

Pregnancy

Due to the expiration of the alphanumeric classification for use in pregnancy and lactation, reference is made to the current, online information of the Teratology Information Service (TIS) of LAREB:

For individual advice, consult an expert on site.
Metadata

Swab vid: M-343511.1
Updated: 06/16/2020 - 16:40
Status: Published

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