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Home Medication antifungal

itraconazol

J - Antiinfectives For Systemic Use -> J02 - Antimycotics For Systemic Use -> J02A - Antimycotics For Systemic Use -> J02AC - Triazole Derivatives -> J02AC02 - Itraconazole
Administration category: Free Medicine group: antifungal Brand name: Trisporal

Safety margins

≥ 18 years
Weight ROA Dosage
ROA:
 po 		Dosage:
 min. 100mg 1 dd to max. 200mg 2 dd
ROA:
 iv 		Dosage:
 min. 100mg 1 dd to max. 200mg 2 dd

Kidney function

≥ 18 years
ROA GFR Dosage Interval Comments
ROA: iv
GFR:
 <30 		Dosage:
 do not prescribe 		Comments:
 oraal mag wel
Renal elimination: 0%
Dosage: independent on kidney function

Renal function-replacement therapy

CAPD: Aanpassen van de dosis of het doseerinterval is niet nodig. Itraconazol is slecht oplosbaar en wordt intraveneus toegediend met de hulpstof hydroxypropylbetadex. Het is onbekend of hydroxypropylbetadex wordt verwijderd door peritoneaal dialyse

Hemo dialysis: Aanpassen van de dosis of het doseerinterval is niet nodig. Itraconazol is slecht oplosbaar en wordt intraveneus toegediend met de hulpstof hydroxypropylbetadex. Hydroxypropylbetadex wordt verwijderd door hemodialyse.

Interactions

Interaction with (ATC): Interaction with: Expected effect:
Interaction with (ATC):
 A02BC - Proton Pump Inhibitors 		Interaction with:
 geldt niet voor drank 		Expected effect:
 verlaging absorptie itraconazol
Interaction with (ATC):
 A02BA - H2-Receptor Antagonists 		Interaction with:
 geldt niet voor drank 		Expected effect:
 verlaging absorptie itraconazol
Interaction with (ATC):
 A03FA02 - Cisapride 		Interaction with:
 		Expected effect:
 toename cardiotoxiciteit cisapride
Interaction with (ATC):
 R06AX12 - Terfenadine 		Interaction with:
 		Expected effect:
 toename cardiotoxiciteit terfenadrine
Interaction with (ATC):
 J01FA09 - Clarithromycin 		Interaction with:
 		Expected effect:
 verhoging plasmaconcentratie itraconazol
Interaction with (ATC):
 C01AA05 - Digoxin 		Interaction with:
 		Expected effect:
 verhoging plasmaconcentratie digoxine
Interaction with (ATC):
 N03AB02 - Phenytoin 		Interaction with:
 		Expected effect:
 sterke verlaging itraconazol plasmaconcentratie
Interaction with (ATC):
 J05AG01 - Nevirapine 		Interaction with:
 		Expected effect:
 verhoging plasmaconcentratie nevirapine en itraconazol
Interaction with (ATC):
 J05AE - Protease Inhibitors 		Interaction with:
 		Expected effect:
 verhoging plasmaconcentratie proteaseremmers
Interaction with (ATC):
 J04AB02 - Rifampicin 		Interaction with:
 		Expected effect:
 verlaging plasmaconcentratie itraconazol
Interaction with (ATC):
 J04AB04 - Rifabutin 		Interaction with:
 		Expected effect:
 verlaging plasmaconcentratie itraconazol
Interaction with (ATC):
 L04AD01 - Ciclosporin 		Interaction with:
 		Expected effect:
 verhoging ciclosporineconcentratie in volbloed
Interaction with (ATC):
 L04AD02 - Tacrolimus 		Interaction with:
 		Expected effect:
 verhoging plasmaconcentratie tacrolimus
Interaction with (ATC):
 L04AA10 - Sirolimus 		Interaction with:
 		Expected effect:
 verhoging plasmaconcentratie sirolimus
Interaction with (ATC):
 B01AA - Vitamin K Antagonists 		Interaction with:
 		Expected effect:
 toename werking orale anticoagulantia

Pregnancy

Due to the expiration of the alphanumeric classification for use in pregnancy and lactation, reference is made to the current, online information of the Teratology Information Service (TIS) of LAREB:

For individual advice, consult an expert on site.
TDM Alert
Metadata

Swab vid: M-2134.2
Updated: 06/16/2019 - 20:05
Status: Published

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